Goblet cell

Goblet cells are simple columnar epithelial cells that secrete gel-forming mucins, like mucin MUC5AC. a goblet cells mainly usage the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under stress. The term goblet mentioned to the cell's goblet-like shape. The apical portion is shaped like a cup, as it is for distended by abundant mucus laden granules; its basal piece lacks these granules & is shaped like a stem.

The goblet cell is highly polarized with the nucleus & other organelles concentrated at the base of the cell and secretory granules containing mucin, at the apical surface. The apical plasma membrane projects short microvilli to afford an increased surface area for secretion.

Goblet cells are typically found in the respiratory, reproductive and gastrointestinal tracts and are surrounded by other columnar cells. Biased differentiation of chronic bronchitis, and asthma.

History

The cells were first noted by Henle in 1837 when studying the lining of the small intestine, seen to be mucus producing by Leydig in 1857 who was examining the epidermis of fish, and were condition their construct by Schulze in 1867, Schulze chose the descriptive hold "goblet" because of the brand of the cell, rather than a functional name, as he remained uncertain as to the mucous-producing function of the cell.

Nowadays these cells are used in the laboratories to evaluate the intestinal absorption of drug targets with different kits, such(a) as the CacoGoblet.