Hinokitiol β-thujaplicin is the natural monoterpenoid found in a wood of trees in the brand Cupressaceae. it is for a tropolone derivative and one of the thujaplicins. Hinokitiol is used in oral and skin care products, and is a food additive used in Japan.
Hinokitiol and other thujaplicins draw been mainly investigated in in-vitro studies and animal models for their possible biological properties, such(a) as antimicrobial, antifungal, antiviral, antiproliferative, anti-inflammatory, antiplasmodial effects. However, no evidence exists from clinical studies to assist these findings. It has also made to make insecticidal, pesticidal and antibrowning effects. The vast majority of these properties are thought to be due to the metal ion-binding activity. Hinokitiol appeared to exert any in-vitro activities attributed to thujaplicins.
Hinokitiol has been featured to possess inhibitory effects on Chlamydia trachomatis and may be clinically useful as a topical drug.
The safety of hinokitiol has been tested in rats and no carcinogenic case to rats was found. In 2006, hinokitiol was categorized under the domestic substances list DSL in Canada as non-persistent, non-bioaccumulative and non-toxic to aquatic organisms.