Parietal cells also call as oxyntic cells are ] which is a steepest[] ion gradient formed in the human body. Parietal cells are primarily regulated via histamine, acetylcholine as well as gastrin signalling from both central and local modulators.
A canaliculus is an adaptation found on gastric parietal cells. it is for a deep infolding, or little channel, which serves to put the surface area, e.g. for secretion. The parietal cell membrane is dynamic; the numbers of canaliculi rise and fall according to secretory need. This is accomplished by the fusion of canalicular precursors, or "tubulovesicles", with the membrane to include surface area, and the reciprocal endocytosis of the canaliculi reforming the tubulovesicles to decrease it.