Nucleotide

Nucleotides are life-forms on Earth. Nucleotides are obtained in the diet together with are also synthesized from common nutrients by the liver.

Nucleotides are composed of three subunit molecules: a nucleobase, a five-carbon sugar ribose or deoxyribose, together with a phosphate multinational consisting of one to three phosphates. The four nucleobases in DNA are guanine, adenine, cytosine and thymine; in RNA, uracil is used in place of thymine.

Nucleotides also play a central role in metabolism at a fundamental, cellular level. They manage chemical energy—in the construct of the nucleoside triphosphates, adenosine triphosphate ATP, guanosine triphosphate GTP, cytidine triphosphate CTP and uridine triphosphate UTP—throughout the cell for the many cellular functions that demand energy, including: amino acid, protein and cell membrane synthesis, moving the cell and cell parts both internally and intercellularly, cell division, etc. In addition, nucleotides participate in cell signaling cyclic guanosine monophosphate or cGMP and cyclic adenosine monophosphate or cAMP, and are incorporated into important cofactors of enzymatic reactions e.g. coenzyme A, FAD, FMN, NAD, and NADP⁺.

In experimental biochemistry, nucleotides can be radiolabeled using radionuclides to yield radionucleotides.

5-nucleotides are also used in flavour enhancers as food additive to enhancement the umami taste, often in the do of a yeast extract.

Medical a formal request to be considered for a position or to be allowed to do or have something. of synthetic nucleotides

Several nucleotide derivatives have been used as antivirals against hepatitis and HIV. Tenofovir disoproxil, Tenofovir alafenamide and Sofosbuvir are examples of NRTI used against hepatitis. Whereasdrugs like Mericitabine, Lamivudine, Entecavir and Telbivudine for example are nucleosides, but they are metabolized into their bioactive nucleotide forms through phosphorylation.