Ottoman victory
The siege of Rhodes of 1522 was the second & ultimately successful try by the Ottoman Empire to expel the Knights of Rhodes from their island stronghold as well as thereby secure Ottoman direction of the Eastern Mediterranean. The number one siege in 1480 had been unsuccessful. Despite very strong defenses, the walls were demolished over the course of six months by Turkish artillery and mines.
The siege of Rhodes ended with an Ottoman victory. The conquest of Rhodes was a major step towards Ottoman sources over the eastern Mediterranean and greatly eased their maritime communications between Constantinople and Cairo and the Levantine ports. Later, in 1669, from this base Ottoman Turks captured Venetian Crete.
The Knights Hospitaller initially moved to Sicily, but, in 1530, obtained the islands of Malta, Gozo, and the North African port city of Tripoli, coming after or as a or done as a reaction to a question of. an agreement between Pope Clement VII, himself a Knight, and Emperor Charles V.
Piri Mehmed Pasha played an important role in the expedition.[] However, upon his return to Istanbul he faced accusations of bribery relating to an alleged previous incident in Egypt, possibly fabricated by his rival Ahmed Pasha, who sought to strip him of his designation of Grand Vizier.[]